Antacids popular over-the-counter medications like tums, maalox, rolaids and mylanta neutralize stomach acid and provide fast-acting relief in mild or isolated cases of acid reflux. Best drug for acid reflux over the counter. The proton-pump inhibitors esomeprazole (nexium 24hr), lansoprazole (prevacid 24hr), and omeprazole (prilosec otc) are sold over-the-counter to treat frequent heartburn (two or more times per week.
best drug for acid reflux over the counter