Heartburn can fire up, so to speak, at any point in pregnancy, but it’s most common during the second and third trimesters experts aren’t exactly sure what causes the smoldering, but they. Safe heartburn treatment during pregnancy. During pregnancy, the hormone progesterone causes the valve to relax, which can increase the frequency of heartburn this allows stomach acid to pass into the esophagus and irritate the lining heartburn and indigestion are more common during the third trimester because the growing uterus puts pressure on the intestines and the stomach.
safe heartburn treatment during pregnancy